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Methylprednisolone is a steroid that prevents the release of substances in the body that cause inflammation. Methylprednisolone is used to treat many different inflammatory conditions such as arthritis, lupus, psoriasis, ulcerative colitis, allergic disorders, gland (endocrine) disorders
Methylprednisolone is a synthetic corticosteroid with mainly glucocorticoid activity and minimal mineralocorticoid properties. It decreases inflammation by suppression of migration of polymorphonuclear leukocytes and reversal of increased capillary permeability.
Onset Peak effect: Oral: 1-2 hours; IM: 4-8 days; Intra-articular: 1 week.
Duration Oral: 30-36 hours; IM: 1-4 weeks; Intra-articular: 1-5 weeks; As acetate, has a low solubility and has sustained IM effect.
Absorption Methylprednisolone is fairly rapidly distributed after oral doses; plasma half-life:≥3.5 hours; tissue half-life: 18-36 hours. As acetate, it is absorbed from joints over a wk but is more slowly absorbed following deep IM injection. As sodium succinate ester, it is rapidly absorbed after IM doses, with peak plasma concentrations in 2 hours.
Distribution: Volume of distribution: 0.7-1.5 L/kg ; crosses the placenta.
Excretion: Half-life elimination: 3-3.5 hours; clearance reduced in obese.
